Edward and Alphonse Elric live in the rural town of Resembool with their mother Trisha, their father Van Hohenheium having left without a reason. Edward since bore a grudge against their father as he and Alphonse showed a talent for alchemy before Trisha died of the plague. After finishing their alchemy training under Izumi Curtis, the brothers attempt to bring their mother back with alchemy. But the transmutation backfires and in law with equivalent exchange, Edward lost his left leg while Alphonse was dragged into the Gate of Truth. Edward sacrifices his right arm to retrieve Alphonse's soul, binding it to a suit of armor with a blood seal. Edward is invited by Roy Mustang to become a State Alchemist to research a way to restore Alphonse's body, passing his exams while given the title of Fullmetal Alchemist back on his prosthetic automail limbs and use of metal in his alchemy. The Elrics spent the next three years searching for the mythical Philosophers Stone to achieve their goals. One such lead resulted in them exposing a corrupt religious leader in the city of Liore while unaware of events occurring behind the scenes by the mysterious Homunculi.